Abstract: Wheat is one of the most widely grown cereals globally. High temperature has reduced the yield and quality in wheat during the flowering and filling stage. Identification and screening heat-tolerant varieties of wheat and performing molecular breeding for heat tolerance is the most effective way to resolve this issue. In this paper, we reviewed the progress on the identification indexes of heat tolerance and molecular makers linked to tolerance traits, and pointed out four chromosome regions associated with the heat tolerance in wheat, and discussed some issues relevant to this topic.