Research Progress on Controlled Release Nano-pesticide Formulation

doi:10.11924/j.issn.1000-6850.casb2022-0383

Abstract

Abstract:

Pesticides play an important role in ensuring agricultural production, increasing grain yield and improving farmers’ living standards. In the process of pesticide control of pests and diseases, the active ingredients are easily degraded or lost due to the unstable physicochemical properties of the pesticides’ active ingredients and the improper application process. The utilization rate of conventional pesticide formulations is only about 20%. At the same time, there are problems such as fast release rate of active ingredients, short duration of pesticide effect and great influence of environmental conditions. Controlled release nano-pesticide formulation is a hot spot in the research of pesticide formulations. Based on the nano-dispersion preparation technology and the slow and controlled release characteristics of pesticide carriers, the serious loss of active ingredients of pesticide can be solved by combining nanotechnology with pesticide characteristics, control target, application environment and application methods, so as to improve the effective utilization rate of pesticide formulations. The active ingredients can be released continuously and stably in a specific time and space according to the requirements of pest control dose, which has met the requirements of pest control economically, safely and effectively. In this study, the research progress of nano-biomaterials in controlled release nano-pesticide formulation was reviewed, and the application prospect of controlled release nano-pesticide formulation was discussed.

Key words: nano-pesticide, carrier material, controlled release, effective utilization rate, application

WANG Run, WEI Yu, LIU Hongyuan, CHEN Feng, SHEN Qinrui, WANG Chunxin. Research Progress on Controlled Release Nano-pesticide Formulation[J]. Chinese Agricultural Science Bulletin, 2023, 39(12): 99-105.

Figures/Tables 1

References 50

[1]	庄武. 农药使用现状及科学用药措施研究[J]. 农业科技与装备, 2021(3):69-70.
[2]	孙长娇, 王琰, 赵翔, 等. 纳米农药剂型与其减施增效机理研究进展[J]. 农药学学报, 2020, 22(2):205-213.
[3]	VILLAVERDE J J, B SEVILLA-MORÁN, C LÓPEZ-GOTI, et al. An overview of nanopesticides in the framework of European legislation-science direct[J]. New pesticides and soil sensors, 2017:227-271.
[4]	WANG A, WANG Y, SUN C, et al. Fabrication, characterization, and biological activity of avermectin nano-delivery systems with different particle sizes[J]. Nanoscale research letters, 2018, 13(1):2. doi: 10.1186/s11671-017-2405-1 pmid: 29318395
[5]	ZHAO P, CAO L, MA D, et al. Synthesis of pyrimethanil-loaded mesoporous silica nanoparticles and its distribution and dissipation in cucumber plants[J]. Molecules, 2017, 22(5):817. doi: 10.3390/molecules22050817 URL
[6]	GUAN W, ZHANG W, TANG L, et al. Fabrication of novel avermectin nanoemulsion using a polyurethane emulsifier with cleavable disulfide bonds[J]. Journal of agricultural & food chemistry, 2018, 66(26):6569-6577.
[7]	WANG C, GUO L, YAO J, et al. Preparation, characterization and antifungal activity of pyraclostrobin solid nanodispersion by self-emulsifying technique[J]. Pest management science, 2019, 75:2785-2793. doi: 10.1002/ps.5390 pmid: 30809936
[8]	CUI J, SUN C, WANG A, et al. Dual-functionalized pesticide nanocapsule delivery system with improved spreading behavior and enhanced bioactivity[J]. Nanomaterials, 2020, 10(2):220. doi: 10.3390/nano10020220 URL
[9]	CAO L D, ZHOU Z L, NIU S J, et al. Positive-charge functionalized mesoporous silica nanoparticles as nanocarriers for controlled 2,4-dichlorophenoxy acetic acid sodium salt release[J]. Journal of agricultural and food chemistry, 2018, 66:6594-6603. doi: 10.1021/acs.jafc.7b01957 pmid: 28640597
[10]	YUSOFF S, KAMARI A, ALJAFREE N. A review of materials used as carrier agents in pesticide formulations[J]. International journal of environmental science and technology, 2016, 13(12):1-18. doi: 10.1007/s13762-015-0834-x URL
[11]	吴灵辉. 纳米技术在精准农业中的应用研究进展[J]. 陕西农业科学, 2021, 67(9):80-85.
[12]	孙长娇, 崔海信, 王琰, 等. 纳米材料与技术在农业上的应用研究进展[J]. 中国农业科技导报, 2016, 18(1):18-25. doi: 10.13304/j.nykjdb.2015.240
[13]	MANATUNGA D C, DE SILVA R M, DE SILVA K M N, et al. pH responsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and hydroxyapatite bi-coated iron oxide nanoparticles[J]. European journal of pharmaceutics & biopharmaceutics, 2017, 117:29-38.
[14]	ZHANG C, PAN D, LI J, et al. Enzyme-responsive peptide dendrimer-gemcitabine conjugate as a controlled-release drug delivery vehicle with enhanced antitumor efficacy[J]. Acta biomaterialia, 2017:153-162.
[15]	ZHOU Y, JIE K, HUANG F, et al. A redox-responsive selenium-containing pillar[5] arene-based macrocyclic amphiphile:synthesis, controllable self-assembly in water, and application in controlled release[J]. Chemical communications, 2017, 53(59):8364-8367. doi: 10.1039/C7CC04779G URL
[16]	ZHAO X, CUI H, WANG Y, et al. Development strategies and prospects of nano-based smart pesticide formulation[J]. Journal of agriculture and food chemistry, 2017, 66(26):6504-6512. doi: 10.1021/acs.jafc.7b02004 URL
[17]	姜建芳. 三种纳米农药制备,性能评价及缓释机理研究[D]. 北京: 中国农业科学院, 2014.
[18]	ZHANG B, YANG X, WANG Y, et al. Heparin modified graphene oxide for pH-sensitive sustained release of doxorubicin hydrochloride[J]. Materials science & engineering C, 2017, 75(1):1998-206.
[19]	LIU C, WANG P, SHEN Z, et al. pH-controlled quaternary ammonium herbicides capture/release by carboxymethyl-beta-cyclodextrin functionalized magnetic adsorbents: Mechanisms and application[J]. Analytica chimica acta, 2015, 901:51-58. doi: 10.1016/j.aca.2015.10.027 URL
[20]	LIU G, LIN G, LIN X, et al. Enzyme and pH dual-responsive avermectin nano-microcapsules for improving its efficacy[J]. Environmental science and pollution research, 2019, 26(11):25107-25116. doi: 10.1007/s11356-019-05804-9
[21]	MO D, LI X, CHEN Y, et al. Fabrication and evaluation of slow-release lignin-based avermectin nano-delivery system with UV-shielding property[J]. Scientific reports, 2021, 11:23248. doi: 10.1038/s41598-021-02664-7 pmid: 34853382
[22]	QIU D, LI Y, FU X, et al. Controlled-release of avermectin from organically modified hydrotalcite-like compound nanohybrids[J]. Chinese journal of chemistry, 2009, 27(3):445-451. doi: 10.1002/cjoc.v27:3 URL
[23]	LIN G, CHEN X, ZHOU H, et al. Elaboration of a feather keratin/carboxymethyl cellulose complex exhibiting pH sensitivity for sustained pesticide release[J]. Journal of applied polymer science, 2018, 135:47160.
[24]	GANTA S, DEVALAPALLY H, SHAHIWALA A, et al. A review of stimuli-responsive nanocarriers for drug and gene delivery[J]. Journal of controlled release, 2008, 126(3):187-204. doi: 10.1016/j.jconrel.2007.12.017 pmid: 18261822
[25]	YWA B, SSA B, XCA B, et al. A new temperature-responsive controlled-release pesticide formulation-poly(N-isopropylacrylamide) modified graphene oxide as the nanocarrier for lambda-cyhalothrin delivery and their application in pesticide transportation[J]. Colloids and surfaces A: Physicochemical and engineering aspects, 2021, 612(5):125987. doi: 10.1016/j.colsurfa.2020.125987 URL
[26]	XU C, CAO L, ZHAO P, et al. Synthesis and characterization of stimuli-responsive poly (2-dimethylamino-ethylmethacrylate)-grafted chitosan microcapsule for controlled pyraclostrobin release[J]. International journal of molecular sciences, 2018, 19(3):854. doi: 10.3390/ijms19030854 URL
[27]	ZHANG Y, YAN J, AVELLAN A, et al. Temperature and pH responsive star polymers as nano-carriers with potential for in vivo agrochemical delivery[J]. ACS nano, 2020, 14(9):10954-10965. doi: 10.1021/acsnano.0c03140 URL
[28]	YIN Y, YANG M, XI J, et al. A sodium alginate-based nano-pesticide delivery system for enhanced in vitro photostability and insecticidal efficacy of phloxine B[J]. Carbohydrate polymers, 2020, 247:116677. doi: 10.1016/j.carbpol.2020.116677 URL
[29]	JIANG Y, CHEN Y, TIAN D, et al. Fabrication and characterization of lignin-xylan hybrid nanospheres as pesticide carriers with enzyme-mediated release property[J]. Soft matter, 2020, 16:9083-9093. doi: 10.1039/D0SM01402H URL
[30]	YAO L, YAN S, DING G, et al. Synthesis, characterization, and application of microbe-triggered controlled-release kasugamycin-pectin conjugate[J]. Journal of agricultural & food chemistry, 2015, 134(17):4263-4268.
[31]	KAZIEM A E, GAO Y, HE S, et al. Synthesis and insecticidal activity of enzyme-triggered functionalized hollow mesoporous silica for controlled release[J]. Journal of agricultural & food chemistry, 2017, 65(36):7854-7864.
[32]	YU Z, XIN S, SONG H, et al. Glutathione-responsive carboxymethyl chitosan nanoparticles for controlled release of herbicides[J]. Materials sciences & applications, 2015, 6(6):591-604.
[33]	KUMAR J, NISAR K, SHAKIL N A, et al. Residue and bio-efficacy evaluation of controlled release formulations of metribuzin against weeds in wheat[J]. Bulletin of environmental contamination & toxicology, 2010, 85(3):357-361.
[34]	YANG Q, HE C, ZHANG Z, et al. Redox-responsive flower-like micelles of poly (L-lactic acid)-b-poly (ethylene glycol)-b-poly (L-lactic acid) for intracellular drug delivery[J]. Polymer the international journal for the science & technology of polymers, 2016, 90:351-362.
[35]	ZHANG H, WANG K, ZHANG P, et al. Redox-sensitive micelles assembled from amphiphilic mPEG-PCL-SS-DTX conjugates for the delivery of docetaxel[J]. Colloids & surfaces B biointerfaces, 2016, 142:89-97.
[36]	CHO H J, CHUNG M, SHIM M S, et al. Engineered photo-responsive materials for near-infrared-triggered drug delivery[J]. Journal of industrial and engineering chemistry, 2015, 31:15-25. doi: 10.1016/j.jiec.2015.07.016 URL
[37]	FENG S, WANG J, ZHANG L, et al. Coumarin-containing light-responsive carboxymethyl chitosan micelles as nanocarriers for controlled release of pesticide[J]. Polymers, 2020, 12(10):2268. doi: 10.3390/polym12102268 URL
[38]	CHEN C, ZHANG G, DAI Z, et al. Fabrication of light-responsively controlled-release herbicide using a nanocomposite[J]. Chemical engineering journal, 2018, 349:101-110. doi: 10.1016/j.cej.2018.05.079 URL
[39]	DING K, YIN Y, YING Y, et al. Synthesis of photoresponsive polymeric propesticide micelles based on PEG for the controlled release of A herbicide[J]. Polymer chemistry, 2016, 7(4):899-904. doi: 10.1039/C5PY01690H URL
[40]	XU Z, GAO Z, SHAO X, et al. Light-triggered release of insecticidally active spirotetramat-enol[J]. Chinese chemical letters, 2018, 29(11):116-118.
[41]	CAO L, ZHANG H, CAO C, et al. Quaternized chitosan-capped mesoporous silica nanoparticles as nanocarriers for controlled pesticide release[J]. Nanomaterials, 2016, 6(7):126. doi: 10.3390/nano6070126 URL
[42]	XIANG Y, HAN J, ZHANG G, et al. Efficient synthesis of starch-regulated porous calcium carbonate microspheres as a carrier for slow-release herbicide[J]. Acs sustainable chemistry & engineering, 2018, 6(3):3649-3653.
[43]	WANG Y, CUI H, SUN C, et al. Construction and evaluation of controlled-release delivery system of abamectin using porous silica nanoparticles as carriers[J]. Nanoscale research letters, 2014, 9(1):1-6. doi: 10.1186/1556-276X-9-1
[44]	XU C, CAO L, ZHAO P, et al. Emulsion-based synchronous pesticide encapsulation and surface modification of mesoporous silica nanoparticles with carboxymethyl chitosan for controlled azoxystrobin release[J]. Chemical engineering journal, 2018, 348:244-254. doi: 10.1016/j.cej.2018.05.008 URL
[45]	WANG C, CUI B, ZHAO X, et al. Preparation and characterization of efficient and safe lambda-cyhalothrin nanoparticles with tunable particle size[J]. Pest management science, 2020, 77(4):2078-2086. doi: 10.1002/ps.v77.4 URL
[46]	YANG D, BO C, WANG C, et al. Preparation and characterization of emamectin benzoate solid nanodispersion[J]. Journal of nanomaterials, 2017:1-9.
[47]	BO C, WANG C, ZHAO X, et al. Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques[J]. Plos One, 2018, 13(1):0191742.
[48]	SHAN Y, CAO L, MUHAMMAD B, et al. Iron-based porous metal-organic frameworks with crop nutritional function as carriers for controlled fungicide release[J]. Journal of colloid and interface science, 2020, 566:383-393. doi: S0021-9797(20)30128-4 pmid: 32018178
[49]	DHARANIVASAN G, SITHANANTHAM S, KANNAN M, et al. Metal oxide nanoparticles assisted controlled release of synthetic insect attractant for effective and sustainable trapping of fruit flies[J]. Journal of cluster science, 2017, 28(4):1-17. doi: 10.1007/s10876-017-1165-5 URL
[50]	LIANG Y, DUAN Y, FAN C, et al. Preparation of kasugamycin conjugation based on ZnO quantum dots for improving its effective utilization[J]. Chemical engineering journal, 2018, 12:129.

剂型	粒径	比表面积	分散性	润湿性	持效期	生物利用率
常规缓释剂	1~10 µm	小	一般	一般	短	低
纳米控释剂	<1 µm	大	好	好	长	高

剂型	粒径	比表面积	分散性	润湿性	持效期	生物利用率
常规缓释剂	1~10 µm	小	一般	一般	短	低
纳米控释剂	<1 µm	大	好	好	长	高