Abstract: As the management foundation of agricultural product in its production process and the first pass of terminal agricultural product consumption safety, environmental safety of agricultural production areas is a crucial guarantee for the quantity and quality safety of agricultural products. Based on the conceptual model of PSR, an evaluation index system of environmental safety of agricultural production areas was established. Using entropy method, comprehensive index method, fuzzy algorithms and diagnosis model, this paper evaluated environmental safety of agricultural production areas in Chengdu from 2010 to 2016 and identified its safety grade and main obstacle factors. The research results showed that (1)Under the synthetic effects of three safety indexes from pressure, state and response, environmental safety of agricultural production areas in Chengdu from 2010 to 2016 is not high on the whole and obviously fluctuant. During this period, these three indexes changed in the same way as the comprehensive index did; (2)In general, Environmental safety grade of agricultural production areas in Chengdu from 2010 to 2016 tended to improve, but the fluctuations still existed. The safety grade was unsafe in 2010 and 2015, less safe in 2011-2014 and safe in 2016; (3) The main barriers of environmental safety of agricultural production areas in Chengdu from 2010-2016 originate from pesticide input intensity, load of livestock manure in farmland, pollution pressure of industrial SO2 emission, urbanization rate, acid rain frequency, air quality, environmental protection expenditure proportion. It was particularly after 2014 that obstacle effects of pesticide input intensity, urbanization rate, air quality, environmental protection expenditure proportion highlighted. Obstacle degrees from pressure and state were the two prominent ones, and obstacle degree of pressure has increased since 2014, while obstacle degree of state has gradually decreased since 2014.