仔猪感染猪等孢球虫后T细胞亚群的动态变化

摘要/Abstract

摘要： 为了研究仔猪感染猪等孢球虫后T细胞亚群的变化规律，应用纯种猪等孢球虫孢子化卵囊人工感染9头6日龄仔猪，分别检测了感染前1d和感染后1、3、6、9、11d (DPI) 外周血中CD3+、CD4+、CD8+T细胞。结果显示，DPI 3，CD3+、CD4+T细胞增加，之后下降，但差异均不显著（p>0.05）；CD8＋T细胞在DPI 6增加，DPI 9达峰值（P<0.05）。CD4+/CD8+值在DPI 6下降，DPI 11达到最低点。表明DPI 3感染仔猪的免疫功能有所增强，而DPI 8后仔猪免疫功能受到抑制。

关键词: PTGS/ RNAi, PTGS/ RNAi, 机理, 模型, 因子, 应用

Abstract: In order to reveal the dynamic changes of the T lymphocyte subgroups in piglets，nine six-day-old piglets were inoculated with Isospora suis sporulated occysts. CD3+, CD4+, CD8+ T cells were checked on before and post the day inoculation 1, 3, 6, 9, 11 (DPI), respectively. Results showed that the amounts of CD3+, CD4+ T cells increased on DPI 3 and then decreased, but the diversity was not significant (p>0.05); however, CD8＋ T cell raised on DPI 6 and reached peak value on DPI 9 (P<0.05). The ratio of CD4+/CD8+ began to descend on DPI 6, and came to the lowest point on DPI 11. Those indicated that the immunological functions of the piglets infected with I. suis were reinforced on DPI 3, however, which were suppressed after DPI 8 .

中图分类号:

S852.72+3

王芳,宁长申,张龙现,菅复春,朱静静,姚雷,张敏. 仔猪感染猪等孢球虫后T细胞亚群的动态变化[J]. 中国农学通报, 2007, 23(9): 4-4.

Wang Fang, Ning Changshen, Zhang Longxian, Jian Fuchun, Zhu Jingjing,Yao Lei, Zhang Min. Dynamic Observation on the T Lymphocyte Subgroups of Piglets Infected with Isospora suis[J]. Chinese Agricultural Science Bulletin, 2007, 23(9): 4-4.

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