Abstract: Aimed at the problem of“attaching importance to macroelement and ignoring medium trace element”in production, the effect of fertilizer on the quality, growth and yield of red jujube was studied by applying fertilizer of different Si, Ca and K concentrations. The results showed that the application of Si, Ca and K fertilizer could improve the growth of jujube leaves and fruits, and the length, wide and area of leaves and diameter of fruit were significantly higher than that of CK, 4 kg/plant had the most obvious effect. The content of organic acids, Vc and soluble sugar in jujubes also increased significantly after fertilization, 4 kg/plant also had the most obvious effect. The application of Si, Ca and K fertilizer could significantly strengthen the resistance of jujube tree to diseases and pests, and reduced dehiscent fruit number and sickness fruit rate and increased dropping shoot ration, weight of single fruit and yield, 4 kg/plant had the most obvious effect, which could increase the yield by 21.8%. This study could provide theoretical basis for the reasonable application of Si, Ca and K fertilizer in production and further study.