Research Progress on Mechanism of Annexin in Zoonotic Helminth Diseases

doi:10.11924/j.issn.1000-6850.casb2025-0017

Abstract

Abstract:

Annexins (Anx) are a class of calcium-dependent phospholipid-binding proteins with unique domains, which play regulatory roles in cellular life activities and are associated with various diseases. This study mainly reviews the structure and classification of Anx, with a focus on the research progress of its immune response mechanisms in important zoonotic helminth infections such as Angiostrongylus cantonensis, Taenia solium, Echinococcus granulosus, Taenia multiceps, and Schistosoma. These studies revealed that Anx participated in immune evasion and promoted the survival of worms in the host through various mechanisms such as anticoagulation, regulation of immune cell apoptosis, and interference with the host coagulation system. It is of great biological significance and application value to deeply understand the mechanism of Anx in zoonotic helminthiasis and provide a theoretical basis for the development of new diagnostic targets, treatment strategies and vaccine design.

Key words: annexin, zoonotic helminth diseases, immune response, mechanism of action, vaccine targets, drug targets

HE Peixia, WANG Zhuo, WANG Mengqi, DUAN Rui, ZHAO Yuyuan, WANG Sirui, SUN Shumin. Research Progress on Mechanism of Annexin in Zoonotic Helminth Diseases[J]. Chinese Agricultural Science Bulletin, 2025, 41(23): 125-132.

Figures/Tables 2

References 26

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寄生虫种类	Anx种类	功能
广州管圆线虫^[19]	Anx A2	Anx A2通过结合AcGal-1和激活凋亡信号通路下游的JNK途径来诱导巨噬细胞凋亡，帮助虫体达到免疫逃避。
猪囊尾蚴^[20]	Anx B1、Anx B2、Anx B3	抗凝血、形成稳定可逆的细胞骨架，构建幼虫发育环境，抑制宿主免疫反应。
细粒棘球蚴^[21]	EgAnx B3	EgAnx B3在PSC入侵最终宿主的过程中起关键作用。
细粒棘球蚴^[21]	EgAnx B38	EgAnx B38参与了PSCs与最终宿主之间的相互作用。其具体功能有待进一步研究。
多头绦虫^[22]	TmAnx B2	TmAnx B2可能在多头绦虫的发育和入侵中间宿主中起重要作用。
多头绦虫^[22]	TmAnx B3	TmAnx B3与宿主-寄生虫的营养和相互作用有关，在成虫发育过程中起关键作用。
血吸虫^[23-24]	Anx B30、Anx B22、SjAnx A13	具有纤溶和抗凝血活性；影响发育和繁殖，并通过外分泌体参与宿主-寄生虫相互作用。

寄生虫种类	Anx种类	功能
广州管圆线虫^[19]	Anx A2	Anx A2通过结合AcGal-1和激活凋亡信号通路下游的JNK途径来诱导巨噬细胞凋亡，帮助虫体达到免疫逃避。
猪囊尾蚴^[20]	Anx B1、Anx B2、Anx B3	抗凝血、形成稳定可逆的细胞骨架，构建幼虫发育环境，抑制宿主免疫反应。
细粒棘球蚴^[21]	EgAnx B3	EgAnx B3在PSC入侵最终宿主的过程中起关键作用。
细粒棘球蚴^[21]	EgAnx B38	EgAnx B38参与了PSCs与最终宿主之间的相互作用。其具体功能有待进一步研究。
多头绦虫^[22]	TmAnx B2	TmAnx B2可能在多头绦虫的发育和入侵中间宿主中起重要作用。
多头绦虫^[22]	TmAnx B3	TmAnx B3与宿主-寄生虫的营养和相互作用有关，在成虫发育过程中起关键作用。
血吸虫^[23-24]	Anx B30、Anx B22、SjAnx A13	具有纤溶和抗凝血活性；影响发育和繁殖，并通过外分泌体参与宿主-寄生虫相互作用。