丹翘灌注液抗炎镇痛作用的研究

doi:10.11924/j.issn.1000-6850.2014-1879

中国农学通报 ›› 2015, Vol. 31 ›› Issue (2): 75-79.doi: 10.11924/j.issn.1000-6850.2014-1879

丹翘灌注液抗炎镇痛作用的研究

魏立琴^1,2,王东升²,苗小楼²,张世栋²,董书伟²,邝晓娇²,杨志强²,余四九¹,严作廷²

(¹甘肃农业大学动物医学院,兰州 730070；²中国农业科学院兰州畜牧与兽药研究所/农业部兽用药物创制重点实验室/甘肃省中兽药工程技术研究中心,兰州 730050）

收稿日期:2014-07-07 修回日期:2015-01-10 接受日期:2014-09-09 出版日期:2015-03-19 发布日期:2015-03-19
通讯作者: 魏立琴
基金资助:
“十二五”国家科技支撑计划项目“奶牛健康养殖重要疾病防控关键技术研究”（2012BAD12B03）；中国农业科学院科技创新工程项目“奶牛疾病防控”；中央级公益性科研院所基本科研业务费项目“奶牛疾病诊断与防治”（1610322014028）。

Anti-inflammatory and Analgesic Activities of Danqiao Perfusate

Wei Liqin^1,2, Wang Dongsheng², Miao Xiaolou², Zhang Shidong², Dong Shuwei², Kuang Xiaojiao², Yang Zhiqiang², Yu Sijiu¹, Yan Zuoting²

(¹College of Veterinary Medicine,Gansu Agricultural University, Lanzhou 730070;²Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS/Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou 730050)

Received:2014-07-07 Revised:2015-01-10 Accepted:2014-09-09 Online:2015-03-19 Published:2015-03-19

摘要/Abstract

摘要： 研究丹翘灌注液的抗炎镇痛作用。采用二甲苯致小鼠耳廓肿胀、棉球致小鼠肉芽肿、小鼠醋酸扭体反应、小鼠福尔马林致痛模型观察丹翘灌注液的抗炎和镇痛作用。40、20、10 g/kg的丹翘灌注液能不同程度的抑制二甲苯引起的小鼠耳廓肿胀、棉球引起的肉芽肿增生；不同程度的减少醋酸引起的小鼠扭体次数和福尔马林引起的舔足时间。结果表明，丹翘灌注液具有抗炎、镇痛的作用。

关键词: 耐旱性, 耐旱性, 生理生化指标, 研究进展

Abstract: To study the anti-inflammatory and analgesic activities of Danqiao perfusate, xylene-induced ear swelling and cotton pellet-induced granuloma tissue formation tests in mice were conducted to evaluate the anti-inflammatory activity , acetic acid-induced writhing response, and formalin tests in mice were conducted to assess the analgesic activity. The results showed that Danqiao perfusate ( 40 g/kg、20 g/kg、10 g/kg) could inhibit xylene-induced ear swelling, suppress granulomatous tissue formation, decrease aceticacid-induced writhing numbers and formalin-induced licking foot times in mice. All of these results suggested that Danqiao perfusate has possess the significant anti-inflammatory and analgesic activities.

魏立琴,王东升,苗小楼,张世栋,董书伟,邝晓娇,杨志强,余四九,严作廷. 丹翘灌注液抗炎镇痛作用的研究[J]. 中国农学通报, 2015, 31(2): 75-79.

Wei Liqin,Wang Dongsheng,Miao Xiaolou,Zhang Shidong,Dong Shuwei,Kuang Xiaojiao,Yang Zhiqiang,Yu Sijiu and Yan Zuoting. Anti-inflammatory and Analgesic Activities of Danqiao Perfusate[J]. Chinese Agricultural Science Bulletin, 2015, 31(2): 75-79.

参考文献

[1] Bartlett P C, Kirk J H, Mather E C. Repeated insemination in Michigan Holstein-Friesian cattle: Incidence, descriptive epidemiology and estimated economic impact[J]. Theriogenology. 1986, 26(3): 309-322.
[2] 李德朋,张桂林,刘文博,等.中药治疗奶牛子宫内膜炎的应用进展[J].中国畜牧兽医,2011(7):168-171.
[3] Paisley L G, Mickelsen W D, Anderson P B. Mechanisms and therapy for retained fetal membranes and uterine infections of cows: A review[J]. Theriogenology. 1986, 25(3): 353-381.
[4] Chan H H, Hwang T L, Su C R, et al. Anti-inflammatory, anticholinesterase and antioxidative constituents from the roots and the leaves of Salvia nipponica Miq. var. formosana[J]. PHYTOMEDICINE. 2011, 18(2-3): 148-150.
[5] 叶剑.丹参的药用成分与药理作用探析[J].陕西中医学院学报,2012(5):71-73.
[6] 孔祥峰,胡元亮,杨龙圣,等.奶牛子宫内膜炎病原菌的分离鉴定及中药的抑菌作用[J].畜牧与兽医,2005(9):15-18.
[7] 牛新华,邱世翠,邸大琳,等.连翘体外抑菌作用的研究[J].时珍国医国药,2002(6):342-343.
[8] 郭际.连翘挥发油抗炎作用及机理研究[D].成都:成都中医药大学,2005.
[9] Kang H S, Lee J Y, Kim C J. Anti-inflammatory activity of arctigenin from Forsythiae Fructus[J]. J Ethnopharmacol. 2008, 116(2): 305-312.
[10] 张祎娜,白佳桦,黄正,等.连翘对奶牛子宫内膜炎致病菌(乳房链球菌和无乳链球菌)生长曲线的影响[J].中国农学通报,2011(17):54-57.
[11] 王洪海,王国卿,郭梦尧,等.中药治疗奶牛子宫内膜炎研究进展[J].中国兽医杂志,2010(8):64-66.
[12] 贾杏林,齐长明.奶牛子宫内膜炎研究进展[J].中国兽医杂志,2005(2):34-36.
[13] 杨江凤.柴藿颗粒主要药效学及安全性研究[D].昆明:云南中医学院,2012.
[14] 刘利敏.藏药短管兔耳草总黄酮抗炎解热镇痛作用研究[D].兰州:兰州大学,2010.
[15] Ali K K B Y, Ashraf A, Biswas N N. Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott[J]. Asian Pacific Journal of Tropical Biomedicine. 2012, 2(9): 722-726.
[16] Owoyele B V, Adebukola O M, Funmilayo A A, et al. Anti- inflammatory activities of ethanolic extract of Carica papaya leaves[J]. Inflammopharmacology. 2008, 16(4): 168-173.
[17] 欧红萍,陆雅娟,严光文,等.复方中药清宫药的抗炎药理学研究[J].中国奶牛,2008(1):17-19
[18] Sun Y H, Dong Y L, Wang Y T, et al. Synergistic Analgesia of Duloxetine and Celecoxib in the Mouse Formalin Test: A Combination Analysis[J]. PLOS ONE. 2013, 8(10).1-13
[19] Chang T N, Huang S S, Chang Y S, et al. Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice[J]. J Agric Food Chem. 2011, 59(17): 9112-9119.
[20] Begum S, Saxena B, Goyal M, et al. Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan[J]. Fitoterapia. 2010, 81(3): 178-184.
[21] 武炜,聂姬锋.罗布麻叶水煎剂抗炎作用的研究[J].安徽农业科学,2013(11):4789-4790.
[22] Sulaiman M R, Perimal E K, Akhtar M N, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice[J]. Fitoterapia. 2010, 81(7): 855-858.
[23] Arumugam P, Priya N G, Subathra M, et al. Anti-inflammatory activity of four solvent fractions of ethanol extract of Mentha spicata L. investigated on acute and chronic inflammation induced rats[J]. Environ Toxicol Pharmacol. 2008, 26(1): 92-95.
[24] Chang H Y, Sheu M J, Yang C H, et al. Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2011: 1-8.
[25] Li M, Shang X, Zhang R, et al. Antinociceptive and anti- inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo[J]. Fitoterapia. 2010, 81(3): 167-172.
[26] Bukhari I A, Dar A, Khan R A. Antinociceptive activity of methanolic extracts of St. John's Wort (Hypericum perforatum) preparation[J]. Pak J Pharm Sci. 2004, 17(2): 13-19.
[27] Guo T, Deng Y X, Xie H, et al. Antinociceptive and anti- inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice[J]. Fitoterapia. 2011, 82(3): 347-351.

丹翘灌注液抗炎镇痛作用的研究

Anti-inflammatory and Analgesic Activities of Danqiao Perfusate

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

关于本刊

作者中心

审者中心

在线期刊

联系我们

[1]	陈和敏, 肖文芳, 陈和明, 吕复兵, 朱根发, 李宗艳, 李佐. 基于CiteSpace的兰花保鲜研究进展及可视化分析[J]. 中国农学通报, 2023, 39(1): 151-164.
[2]	李星星, 韩芳, 周雪, 苏乐平, 袁宏安. 富硒谷子研究进展[J]. 中国农学通报, 2022, 38(7): 1-6.
[3]	刘鹏, 吴巧花, 舒惠理, 周莉荫, 王小东. 油茶对胁迫因子的响应机制研究进展[J]. 中国农学通报, 2022, 38(7): 24-28.
[4]	罗志明, 覃伟, 尹炯, 李银煳, 张荣跃, 李俊. 甘蔗种质对甘蔗蓟马的耐害性研究[J]. 中国农学通报, 2022, 38(34): 107-112.
[5]	颜越, 金荷仙, 王丽娴. 国内外社区花园健康效益研究进展[J]. 中国农学通报, 2022, 38(34): 68-75.
[6]	杨武广, 王君, 温凯, 仇景涛. 中国稻鳖共作技术研究进展与展望[J]. 中国农学通报, 2022, 38(31): 12-16.
[7]	王晴, 方文生, 李园, 王秋霞, 颜冬冬, 曹坳程. 杀线虫剂新品种及作用机制研究进展[J]. 中国农学通报, 2022, 38(30): 100-107.
[8]	麻磊, 黄晓君, Ganbat Dashzebegd, Mungunkhuyag Ariunaad, Tsagaantsooj Nanzadd, Altanchimeg Dorjsuren, 包刚, 佟斯琴, 包玉海, Enkhnasan Davaadorj. 不同遥感传感器监测森林虫害研究进展与展望[J]. 中国农学通报, 2022, 38(26): 91-99.
[9]	张瑞玖, 马恢, 籍立杰, 任德志, 李双东, 张耀辉, 王莉红. 干旱胁迫对马铃薯品种生长及生理生化指标的影响[J]. 中国农学通报, 2022, 38(15): 34-39.
[10]	厉雅华, 张向前, 安祺, 武迪, 刘战勇, 孙峰, 张德健, 高敏, 张国英, 邢俊. 耕地地力评价方法及实践应用研究进展[J]. 中国农学通报, 2022, 38(15): 60-68.
[11]	彭婵, 张新叶, 刘宗坤, 马林江, 陈慧玲. 石斛属植物SSR分子标记的研究进展[J]. 中国农学通报, 2022, 38(13): 36-40.
[12]	吴文彦, 程智超, 李梦莎, 隋心, 曾宪楠. 基于Web of Science的根瘤菌发展研究[J]. 中国农学通报, 2021, 37(9): 109-117.
[13]	崔国梅, 许方方, 李顺峰, 魏书信, 刘丽娜, 王安建. 香菇精深加工及生物活性研究进展[J]. 中国农学通报, 2021, 37(7): 132-137.
[14]	范馨月, 张华, 赵继业, 杜子沫, 丛日晨. 绒毛白蜡耐盐碱响应机制的研究进展[J]. 中国农学通报, 2021, 37(28): 28-34.
[15]	张旭, 胡宝贵. 中国农业节水灌溉技术应用研究进展[J]. 中国农学通报, 2021, 37(26): 153-158.