Abstract: A comprehensive culture technique for the Hybrid Rice liangyouduoxi 1 was studied by the method of optimization design. Four influential elements were planting density(x1),seedling age(x2), quantities of nitrogen(x3) and potassium（x4）.The regression models of four elements with yield were established. The results showed that four elements affected the yield. After simulated screening and optimal by computer, the comprehensive culture techniques of high yield were 148000~281000 hills per hm2, 32~33 days for transplanting, 96.9~167.7kg N and 147.5~169.8 kg K2O per hm2.