Abstract: As a kind of triazine herbicides, prometryn has been applied illegally in aquaculture. In recent years, prometryn residue in aquatic products in China has been frequently detected, and even exceeded the baseline of command check set by aquatic products import countries, affecting the normal export trade of aquatic products. However, the maximum residue limit (MRL) of prometryn in aquatic products has not been reported yet. As prometryn is difficult to degrade, it may be a potential safety hazard to aquatic environment. In order to attract widespread concern and attention, and provide basic data for bringing prometryn into the national standard directory as veterinary drugs and establishing normal export trade order of aquatic products, status of prometryn residue limited standards at home and abroad were analyzed in this paper based on the reports on prometryn of Environmental Protection Agency (EPA), safety evaluation of prometryn on human health was introduced in detail, ecotoxicological effects of prometryn on aquatic environment were summarized, and the detection methods of prometryn in aquatic products and related risk assessment research status were reviewed.