In view of the shortage of water and heat resources in different ecological areas, and the frequent occurrence of wind disaster, lodging, low yield, poor quality and other problems in maize production, a new maize variety ‘MC278’ was bred by taking ‘Jing X005’ as female parent and ‘Jing 27’ as male parent. The inoculation tests of the variety in Jilin, Hebei and other places showed that it had strong resistance to small spot disease, Curvularia, dwarf mosaic, silk smut and stem rot, and was easy to infect large leaf spot, and it was moderately resistant to corn borer in Jilin. In the regional trials in Beijing, Inner Mongolia and other regions in different years, the kernel yield of ‘MC278’ was significantly higher than that of ‘Zhengdan 958’ (CK), the highest yield was 16166 kg/hm2, and the average yield was increased by 8.3%. The content of crude protein, crude starch and lysine of ‘MC278’ were significantly higher than those of ‘Zhengdan 958’. In 2019, the production in Hebei, Shanxi, Inner Mongolia and other regions showed that the yield of ‘MC278’ was all more than 12804 kg/hm2, and the maximum yield was 14283 kg/hm2. ‘MC278’ was equipped with field management measures and harvest techniques, such as suitable sowing date, density and water and fertilizer management, and prevention and control measures of diseases and insect pests. The variety passed the national examination and approval in 2019 (National Approved Maize Variety No.20190030), and its planting area now includes 15 provincial regions, such as Anhui, Shanxi, Shandong and etc.