Advances in Scientific Research on Andrographis paniculata

doi:10.11924/j.issn.1000-6850.casb2021-1204

Abstract

Abstract:

This study aims to understand the research status and disciplinary development of Andrographis paniculata (AP). By searching the core collection of Web of Science (WoS) SCI academic papers published from 2001 to 2020, and combining with bibliometrics descriptive and correlation indicators, the research situation of AP in the 20 years was clarified. The results are as follows. (1) In 2019-2020, the annual number of papers published on AP exceeded 100, most of which focused on the anti-cancer function of andrographolide. (2) Although India, China and Malaysia were the countries with the largest number of publications, China had the most recent coauthored relationships with the United States and Australia. Considering the number of papers published, H index and annual citations of papers, the United States achieved international influence equal to that of China with only 1/5 of the published papers of China. The research results of the United States were highly valued, and the quality of Chinese papers still needs to be improved. (3) The most frequently cited research institutions of AP were CSIR and the National University of Singapore. China Medical University in Taiwan, Chinese Academy of Sciences, Shanghai University of Traditional Chinese Medicine and Sun Yat-sen University of Medical Science were the major research institutions of AP in China. (4) The top 3 authors with the largest number of papers were all from China. (5) Wong W S F’s team of the National University of Singapore published an academic paper in 2009 with the highest impact factor (21.4) so far, illustrating the molecular mechanism of andrographolide in relieving asthma. With the disclosure of the function of ‘natural antibiotic’ andrographolide in inhibiting COVID-19 protein activity, international scholars have attached great importance to it, and the basic research on the pharmacological effect and high and stable yield of AP will be further deepened.

Key words: Andrographis paniculata, andrographolide, Web of Science, bibliometrics, visualization

CLC Number:

SUN Mingyang, XU Shiqiang, ZHANG Wenting, GU Yan, MEI Yu, LI Jingyu, ZHOU Fang, WANG Jihua. Advances in Scientific Research on Andrographis paniculata[J]. Chinese Agricultural Science Bulletin, 2022, 38(34): 155-164.

Figures/Tables 14

References 30

[1]	NIRANJAN A, TEWARI S K, LEHRI A. Biological activities of Kalmegh (Andrographis paniculata Nees) and its active principles-A review[J]. Indian journal of natural products and resources, 2010, 1(2):125-135.
[2]	SHI T H, HUANG Y L, CHEN C C, et al. Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage[J]. Biochemical and biophysical research communications, 2020, 533(3): 467-473. doi: 10.1016/j.bbrc.2020.08.086 URL
[3]	任全娥. 大数据背景下的文献计量学研究进展与学科融合[J]. 情报理论与实践, 2019, 42(1):52-56.
[4]	付全升, 黄先寒, 申仕康, 等. 基于数据库的植物功能性状研究现状文献计量学分析[J]. 应用与环境生物学报, 2021(1):228-240.
[5]	付健, 丁敬达. Citespace和VOSviewer软件的可视化原理比较[J]. 农业图书情报, 2019, 31(10):33-39.
[6]	宋秀芳, 迟培娟. VOSviewer与Citespace应用比较研究[J]. 情报科学, 2016, 34(7):108-112.
[7]	GUPTA B M, MUEEN A K K, DHAWAN S M, et al. Aloe vera (medicinal plant) research: A scientometric assessment of global publications output during 2007-16[J]. Pharmacognosy journal, 2018, 10(1):394-402. doi: 10.5530/pj.2018.3.65 URL
[8]	GUPTA B M, DHAWAN S M, GUPTA R. Phyllanthis emblica (medicinal plant) research: A scientometric assessment of global publications output during 2008-17[J]. EC Pharmacol Toxicol, 2019, 7(1):18-28.
[9]	MUEEN A K K, GUPTA B M, GUPTA R. Curcuma longa (medicinal plant) research: A scientometric assessment of global publications output during 1997-2016[J]. Pharmacognosy journal, 2018, 10(5):998-1006. doi: 10.5530/pj.2018.5.170 URL
[10]	GUPTA G, AHMED K, BANSAL J, et al. Andrographis paniculata global publications output: A bibliometric assessment during 2003-18[J]. International journal of pharmaceutical investigation, 2019, 9(3):101-108. doi: 10.5530/ijpi.2019.3.20 URL
[11]	唐朝臣, 黄立飞, 王章英. 国内外甘薯研究态势述评[J]. 中国农业大学学报, 2020, 25(7):51-68.
[12]	赵艺哲. 文献计量指标在青年科学家学术绩效评价中的应用研究——以国家杰出青年科学基金获得者为例[D]. 北京: 北京理工大学, 2016.
[13]	刘婧. 文献作者分布规律研究——对近十五年来国内洛特卡定律、普赖斯定律研究成果综述[J]. 情报科学, 2004, 22(1):123-128.
[14]	CHEN H W, HUANG C S, LI C C, et al. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats[J]. Toxicology and applied pharmacology, 2014, 280(1):1-9. doi: 10.1016/j.taap.2014.07.024 URL
[15]	DESAI A G, QAZI G N, GANJU R K, et al. Medicinal plants and cancer chemoprevention[J]. Current drug metabolism, 2008, 9(7):581-591. doi: 10.2174/138920008785821657 pmid: 18781909
[16]	GOVINDARAJAN R, VIJAYAKUMAR M, PUSHPANGADAN P. Antioxidant approach to disease management and the role of 'Rasayana' herbs of Ayurveda[J]. Journal of ethnopharmacology, 2005, 99(2):165-178. pmid: 15894123
[17]	AJAYAKUMAR R. Anticancer and immunostimulatory compounds from Andrographis paniculate[J]. Journal of ethnopharmacology, 2004, 92(2-3):291-295. doi: 10.1016/j.jep.2004.03.004 URL
[18]	SUBRAMANIAN R, ASMAWI M Z, SADIKUN A. In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide[J]. Acta biochimica polonica, 2008, 55(2):391-398. doi: 10.18388/abp.2008_3087 URL
[19]	SHEN Y C, CHEN C F, CHIOU W F. Andrographolide prevents oxygen radical production by human neutrophils: Possible mechanism(s) involved in its anti-inflammatory effect[J]. British journal of pharmacology, 2010, 135(2):399-406. doi: 10.1038/sj.bjp.0704493 URL
[20]	XIA Y F, YE B Q, LI Y D, et al. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50[J]. Journal of immunology, 2004, 173(6):4207-4217. doi: 10.4049/jimmunol.173.6.4207 URL
[21]	ZHU T, WANG D X, ZHANG W, et al. Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB[J]. Plos one, 2013, 8(2):e56407. doi: 10.1371/journal.pone.0056407 URL
[22]	BAO Z, GUAN S, CHANG C, et al. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappa B pathway[J]. American journal of respiratory and critical care medicine, 2012, 179(8):657-665. doi: 10.1164/rccm.200809-1516OC URL
[23]	LIM J C W, CHAN T K, NG D S W, et al. Andrographolide and its analogues: Versatile bioactive molecules for combating inflammation and cancer[J]. Clinical and experimental pharmacology and physiology, 2012, 39(3):300-310. doi: 10.1111/j.1440-1681.2011.05633.x pmid: 22017767
[24]	SUN W, LENG L, YIN Q G, et al. The medicinal plant Andrographis paniculata genome provides insight into biosynthesis of the bioactive diterpenoid neoandrographolide[J]. The plant journal, 2019, 97(5):841-857. doi: 10.1111/tpj.14162 URL
[25]	TRAN Q T N, TAN W S D, WONG W S F, et al. Polypharmacology of andrographolide: Beyond one molecule one target[J]. Natural product reports, 2020, 38(4):682-692. doi: 10.1039/D0NP00049C URL
[26]	ADIGUNA S P, PANGGABEAN J A, ATIKANA A, et al. Antiviral activities of andrographolide and its derivatives: mechanism of action and delivery system[J]. Pharmaceuticals, 2021, 14(11):1102. doi: 10.3390/ph14111102 URL
[27]	KHUNTIA B K, SHARAMA V, WADHAWAN M, et al. Antiviral potential of Indian medicinal plants against influenza and SARS-CoV: A systematic review[J]. Natural product communications, 2022, 17(3):1934578X221086988.
[28]	ZENG B, WEI A, ZHOU Q, et al. Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches[J]. Phytotherapy research, 2022, 36(1):336-364. doi: 10.1002/ptr.7324 URL
[29]	邬亚文, 夏小东, 职桂叶, 等. 基于文献的国内外水稻研究发展态势分析[J]. 中国农业科学, 2011, 44(20):4129-4141.
[30]	BAO Z, GUAN S, CHENG C, et al. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-κB pathway[J]. American journal of respiratory and critical care medicine, 2009, 179(8):657-665. doi: 10.1164/rccm.200809-1516OC URL

关联性指标	筛选标准
标题和摘要的高频词共现	共现次数≥50
关键词聚类	共现次数≥25
互引国家	发表文章≥25篇，国家总被引数≥320
合著国家	发表文章≥25篇，国家总被引数≥500
互引机构	发表文章≥20篇，机构总被引数≥100
机构研究内容相关性	发表文章≥20篇，机构总被引数≥100
合著作者	发表文章≥10篇，个人总被引数≥200

关联性指标	筛选标准
标题和摘要的高频词共现	共现次数≥50
关键词聚类	共现次数≥25
互引国家	发表文章≥25篇，国家总被引数≥320
合著国家	发表文章≥25篇，国家总被引数≥500
互引机构	发表文章≥20篇，机构总被引数≥100
机构研究内容相关性	发表文章≥20篇，机构总被引数≥100
合著作者	发表文章≥10篇，个人总被引数≥200

国家	发文量	H指数	最高被引文章
国家	发文量	H指数	年均被引频次	总被引数	发表年份
印度	378	44	15.89	286	2004
中国	343	47	15.33	276	2004
马来西亚	136	29	13.29	186	2008
泰国	89	27	6.78	122	2004
美国	73	30	15.33	276	2004
澳大利亚	26	14	12.71	89	2015
日本	26	12	7.57	106	2008
新加坡	25	19	12.85	167	2009
伊朗	22	11	13.25	53	2018
韩国	21	13	8.22	74	2013

国家	发文量	H指数	最高被引文章
国家	发文量	H指数	年均被引频次	总被引数	发表年份
印度	378	44	15.89	286	2004
中国	343	47	15.33	276	2004
马来西亚	136	29	13.29	186	2008
泰国	89	27	6.78	122	2004
美国	73	30	15.33	276	2004
澳大利亚	26	14	12.71	89	2015
日本	26	12	7.57	106	2008
新加坡	25	19	12.85	167	2009
伊朗	22	11	13.25	53	2018
韩国	21	13	8.22	74	2013

科研机构	发文量	H指数	总被引频次（除自引）
马来西亚博特拉大学	59	16	955
印度科学工业研究理事会(CSIR)	58	21	1469
马希隆大学	34	15	793
台湾中华医科大学	31	17	910
中国科学院	27	17	904
马来西亚理科大学	27	14	592
新加坡国立大学	24	19	1294
印度农业研究理事会(ICAR)	22	7	151
上海中医药大学	22	15	501
中山医学大学	21	15	815