Research Progress of Effects of Vitamin A on Reproductive Performance of Male Animals

doi:10.11924/j.issn.1000-6850.casb2022-0582

Abstract

Abstract:

In modern animal husbandry, with the wide application of artificial insemination technology, the requirements for semen quality of male animals have been rising. Nutritional regulation is one of the most important methods to improve animal reproductive performance and increase economic efficiency. As one of the essential nutrients for animals, vitamin A has an important role in regulating the reproductive performance of male animals, in addition to promoting bone development, maintaining metabolism and regulating embryonic growth. This paper briefly describes the properties and metabolism of vitamin A and its effects on the reproductive performance of male animals, in order to provide a theoretical reference for improving the fertility of breeding animals through nutritional regulation technology.

Key words: vitamin A, male animals, reproductive performance, research progress, mechanism

LU Siyu, LI Jingxuan, WANG Yan, LONG Cheng, CHEN Li, GUO Yong, QI Xiaolong. Research Progress of Effects of Vitamin A on Reproductive Performance of Male Animals[J]. Chinese Agricultural Science Bulletin, 2023, 39(20): 119-124.

References 84

[1]	金洪玲, 王莹. 种公猪繁殖性能的营养影响因素[J]. 吉林畜牧兽医, 2020, 41(1):22,25.
[2]	YOKOTA S, SEKINE N, WAKAYAMA T, et al. Impact of chronic vitamin A excess on sperm morphogenesis in mice[J]. Andrology, 2021, 9(5):1579-1592. doi: 10.1111/andr.13013 pmid: 33818007
[3]	李璇. 维甲酸改善复合药物诱导的小鼠生精障碍并上调睾丸CCND1的表达[D]. 衡阳: 南华大学, 2020.
[4]	张娜娜, 曹洪战, 芦春莲. 维生素A在家禽生产上应用的研究[J]. 饲料广角, 2015(18):31-33.
[5]	HUANG Z, LIU Y, QI G, et al. Role of vitamin A in the immune system[J]. Journal of clinical medicine, 2018, 7(9):258. doi: 10.3390/jcm7090258 URL
[6]	CLAGETT-DAME M, KNUTSON D. Vitamin A in reproduction and development[J]. Nutrients, 2011, 3(4):385-428. doi: 10.3390/nu3040385 URL
[7]	CORBO J C. Vitamin A1/A2 chromophore exchange: Its role in spectral tuning and visual plasticity[J]. Developmental biology, 2021, 475:145-155. doi: 10.1016/j.ydbio.2021.03.002 URL
[8]	金鹿, 闫素梅, 史彬林, 等. 维生素A抗氧化功能的机制[J]. 动物营养学报, 2015, 27(12):3671-3676. doi: 10.3969/j.issn.1006-267x.2015.12.004
[9]	张文生. 鸡维生素A缺乏症的发生原因、临床特征、鉴别诊断和防治措施[J]. 现代畜牧科技, 2021(6):145-146.
[10]	耿江, 殷爽, 刘兆辉. 鸡维生素A缺乏症的防治措施[J]. 中国畜禽种业, 2021, 17(12):188-189.
[11]	俞安, 尹红, 陈志荣, 等. 维生素A稳定性影响因素研究进展[J]. 中国食品学报, 2013(1):124-131.
[12]	INEROWICZ H D, NOVOTNY L, RAMSEY C A, et al. Effect of test portion mass on vitamin A testing in animal feed materials[J]. Journal of AOAC international, 2022, 105(1):288-298. doi: 10.1093/jaoacint/qsab158 URL
[13]	CARAZO A, MACáKOVá K, MATOUšOVá K, et al. Vitamin A update: Forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity[J]. Nutrients, 2021, 13(5):1703. doi: 10.3390/nu13051703 URL
[14]	TAKAHASHI N, SAITO D, HASEGAWA S, et al. Vitamin A in health care: Suppression of growth and induction of differentiation in cancer cells by vitamin A and its derivatives and their mechanisms of action[J]. Pharmacology & therapeutics, 2021:107942.
[15]	张利环, 杨燕燕, 张春善, 等. 肉仔鸡对维生素A需要量的研究进展[J]. 黑龙江畜牧兽医, 2010(7):37-39.
[16]	SENOO H, MEZAKI Y, FUjIWARA M. The stellate cell system (vitamin A-storing cell system)[J]. Anatomical science international, 2017, 92(4):387-455. doi: 10.1007/s12565-017-0395-9 pmid: 28299597
[17]	徐海涛. 维生素A对感染病毒雄鼠繁殖性能和免疫功能的保护效应[D]. 成都: 四川农业大学, 2008.
[18]	THEODOSIOU M, LAUDET V, SCHUBERT M. From carrot to clinic: An overview of the retinoic acid signaling pathway[J]. Cellular and molecular life sciences, 2010, 67(9):1423-1445. doi: 10.1007/s00018-010-0268-z pmid: 20140749
[19]	ZHANG T, SUN P, GENG Q, et al. Disrupted spermatogenesis in a metabolic syndrome model: The role of vitamin A metabolism in the gut-testis axis[J]. Gut, 2022, 71(1):78-87. doi: 10.1136/gutjnl-2020-323347 pmid: 33504491
[20]	李嵩. 围产期奶牛日粮不同维生素A添加水平对免疫功能,生产性能和繁殖机能的影响[D]. 呼和浩特: 内蒙古农业大学, 2010.
[21]	杨桂林. 饲料中维生素水平对猪繁殖性能的影响[J]. 现代畜牧科技, 2017(4):68-68.
[22]	WALKER W H. Androgen Actions in the Testis and the Regulation of Spermatogenesis[J]. Molecular mechanisms in spermatogenesis, 2021:175-203.
[23]	WANG Y J, JIA G X, YAN R G, et al. Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae)[J]. Theriogenology, 2019, 123:74-82. doi: 10.1016/j.theriogenology.2018.09.033 URL
[24]	OGBUEWU I P, OKORO V M, MBAjIORGU E F, et al. Supplementation of vitamin A to local chicken diets in tropical environment enhances seminal quality and blood testosterone concentration[J]. Tropical animal health and production, 2020, 52(4):2101-2109. doi: 10.1007/s11250-020-02224-7 pmid: 32056072
[25]	代航. 饲粮添加维生素A对种鹅繁殖性能,抗氧化性和组织维生素A沉积量的影响[D]. 扬州: 扬州大学, 2019.
[26]	MILLER D H, BRADLEY J W, FERGUSON T M. Effect of vitamin A and protein levels on growth and semen quality of turkeys[J]. Poultry science, 1977, 56(4):1086-1091. pmid: 605072
[27]	YOKOTA S, SHIRAHATA T, YUSA J, et al. Long-term dietary intake of excessive vitamin A impairs spermatogenesis in mice[J]. The journal of toxicological sciences, 2019, 44(4):257-271. doi: 10.2131/jts.44.257 URL
[28]	LIVERA G, ROUILLER-FABRE V, PAIRAULT C, et al. Regulation and perturbation of testicular functions by vitamin A[J]. Reproduction, 2002, 124(2):173-180. pmid: 12141930
[29]	APPLING D R, CHYTIL F. Evidence of a role for retinoic acid (vitamin A-acid) in the maintenance of testosterone production in male rats[J]. Endocrinology, 1981, 108(6):2120-2123. pmid: 7227300
[30]	ZERVOS I A, TSANTARLIOTOU M P, VATZIAS G, et al. Effects of dietary vitamin A intake on acrosin-and plasminogen-activator activity of ram spermatozoa[J]. Reproduction, 2005, 129(6):707-715. doi: 10.1530/rep.1.00182 URL
[31]	李建国, 陆治年, 金穗华, 等. 维生素A对乳用种公牛精液品质和某些生化指标的影响[J]. 南京农业大学学报, 1990, 13(2):100-105.
[32]	ABDULKAREEMA T A, AL-HABOBYB A H, AL-MjAMEIA S M, et al. Sperm abnormalities associated with vitamin A deficiency in rams[J]. Small ruminant research, 2005, 57(1):67-71. doi: 10.1016/j.smallrumres.2004.06.017 URL
[33]	李雪梅, 曾饶琼, 易宗容, 等. 维生素A饲喂量对种公猪精液品质的影响[J]. 安徽农业科学, 2008, 36(33):14540-14540.
[34]	CHEN X, LI Y, DAI H, et al. Cyclin-dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway[J]. IUBMB life, 2021, 73(12):1446-1459. doi: 10.1002/iub.v73.12 URL
[35]	杜松献, 胡文平. 夏洛来种公牛的营养[J]. 河南畜牧兽医, 2000(7):19-20.
[36]	PLANT T M. 60 YEARS OF Neuroendocrinology: The hypothalamo-pituitary-gonadal axis[J]. Journal of endocrinology, 2015, 226(2):T41-T54. doi: 10.1530/JOE-15-0113 URL
[37]	WANG H Q, ZHANG W D, YUAN B, et al. Advances in the regulation of mammalian follicle-stimulating hormone secretion[J]. Animals, 2021, 11(4):1134. doi: 10.3390/ani11041134 URL
[38]	张莹, 马佳男, 王佳丽, 等. 生命早期应激对青春期雄性大鼠下丘脑-垂体-性腺轴的影响[J]. 生殖医学杂志, 2021, 30(11):1500-1505.
[39]	ZIRKIN B R, PAPADOPOULOS V. Leydig cells: Formation, function, and regulation[J]. Biology of reproduction, 2018, 99(1):101-111. doi: 10.1093/biolre/ioy059 pmid: 29566165
[40]	SIU M K Y, CHENG C Y. Dynamic cross-talk between cells and the extracellular matrix in the testis[J]. Bioessays, 2004, 26(9):978-992. pmid: 15351968
[41]	DU L, CHEN W, CHENG Z, et al. Novel gene regulation in normal and abnormal spermatogenesis[J]. Cells, 2021, 10(3):666. doi: 10.3390/cells10030666 URL
[42]	HIGUCHI K, MATSUMURA T, AKIYAMA H, et al. Sertoli cell replacement in explanted mouse testis tissue supporting host spermatogenesis[J]. Biology of reproduction, 2021, 105(4):934-943. doi: 10.1093/biolre/ioab104 pmid: 34057178
[43]	刘建中, 郭海彬, 邓春华, 等. 大鼠睾丸Leydig细胞的培养和鉴定[J]. 中华男科学杂志, 2006, 12(1):14-17.
[44]	ODUWOLE O O, HUHTANIEMI I T, MISRAHI M. The Roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited[J]. International journal of molecular sciences, 2021, 22(23):12735. doi: 10.3390/ijms222312735 URL
[45]	NOURASHRAFEDDIN S, RASHIDI B H. Gonadotropin regulation of retinoic acid activity in the testis[J]. Acta medica iranica, 2018:34-42.
[46]	KHANEHZAD M, ABBASZADEH R, HOLAKUYEE M, et al. FSH regulates RA signaling to commit spermatogonia into differentiation pathway and meiosis[J]. Reproductive biology and endocrinology, 2021, 19(1):1-19. doi: 10.1186/s12958-020-00681-1
[47]	NOURASHRAFEDDIN S. Potential roles of gonadotropins to control pulsatile retinoic acid signaling during spermatogenesis[J]. Medical hypotheses, 2015, 85(3):303-304. doi: 10.1016/j.mehy.2015.05.021 pmid: 26141633
[48]	PASCALE A, MARCHESI N, MARELLI C, et al. Microbiota and metabolic diseases[J]. Endocrine, 2018, 61(3):357-371. doi: 10.1007/s12020-018-1605-5 pmid: 29721802
[49]	LEVKOVICH T, POUTAHIDIS T, SMILLIE C, et al. Probiotic bacteria induce a ‘glow of health’[J]. Plos one, 2013, 8(1):e53867. doi: 10.1371/journal.pone.0053867 URL
[50]	POUTAHIDIS T, SPRINGER A, LEVKOVICH T, et al. Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice[J]. Plos one, 2014, 9(1):e84877. doi: 10.1371/journal.pone.0084877 URL
[51]	SCOLARI F, ATTARDO G M, AKSOY E, et al. Symbiotic microbes affect the expression of male reproductive genes in Glossina m. morsitans[J]. BMC microbiology, 2018, 18(1):117-133. doi: 10.1186/s12866-018-1259-8
[52]	ZHANG P, FENG Y, LI L, et al. Improvement in sperm quality and spermatogenesis following faecal microbiota transplantation from alginate oligosaccharide dosed mice[J]. Gut, 2021, 70(1):222-225. doi: 10.1136/gutjnl-2020-320992 pmid: 32303608
[53]	KUO W T, ZUO L, ODENWALD M A, et al. The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair[J]. Gastroenterology, 2021, 161(6):1924-1939. doi: 10.1053/j.gastro.2021.08.047 URL
[54]	DING N, ZHANG X, D ZH X, et al. Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes[J]. Gut, 2020, 69(9):1608-1619. doi: 10.1136/gutjnl-2019-319127 pmid: 31900292
[55]	KARAKAS S E, SURAMPUDI P. New biomarkers to evaluate hyperandrogenemic women and hypogonadal men[J]. Advances in clinical chemistry, 2018, 86:71-125. doi: S0065-2423(18)30035-0 pmid: 30144842
[56]	吴应积. 视黄酸在精子发生过程中引发减数分裂的信号通路[J]. 中华男科学杂志, 2013, 19(2):173-177.
[57]	DUFOUR J M, KIM K H. Cellular and subcellular localization of six retinoid receptors in rat testis during postnatal development: Identification of potential heterodimeric receptors[J]. Biology of reproduction, 1999, 61(5):1300-1308. pmid: 10529278
[58]	MCANINCH D, THOMSON E P, THOMAS P Q. Genome-wide DNA-binding profile of SRY-box transcription factor 3 (SOX3) in mouse testes[J]. Reproduction, fertility and development, 2020, 32(16):1260-1270. doi: 10.1071/RD20108 pmid: 33166488
[59]	IKAMI K, TOKUE M, SUGIMOTO R, et al. Hierarchical differentiation competence in response to retinoic acid ensures stem cell maintenance during mouse spermatogenesis[J]. Development, 2015, 142(9):1582-1592. doi: 10.1242/dev.118695 pmid: 25858458
[60]	李伟伟, 闫娅妮, 史鸿志, 等. PRM1基因C321A,G197T单核苷酸多态性对体外受精结局的影响[J]. 生殖医学杂志, 2017, 26(4):362-365.
[61]	孙昌瑞, 冯林. 男性不育患者PRM1和PRM2mRNA表达的研究[J]. 第二届中国临床分子诊断大会论文集, 2019.
[62]	TOSHINOBU M, SHIGA H, LEAH Y, et al. Azoospermia in patients heterozygous for a mutation in SYCP3[J]. The lancet, 2003, 362(9397).
[63]	SCHRAMM S, FRAUNE J, NAUMANN R, et al. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility[J]. Plos genetics, 2011, 7(5):e1002088.
[64]	SNYDER E M, DAVIS J C, ZHOU Q, et al. Exposure to retinoic acid in the neonatal but not adult mouse results in synchronous spermatogenesis[J]. Biology of reproduction, 2011, 84(5):886-893. doi: 10.1095/biolreprod.110.089755 pmid: 21228214
[65]	黄建喜, 彭陈岑, 阿周存. 无精症少弱精症与生精障碍的研究进展[J]. 中国实用医药, 2010(16):256-258.
[66]	YUE M, FAN X, LIU Y, et al. Effects of body temperature on the expression and localization of meiosis-related proteins STRA8 and SCP3 in boar testes[J]. Acta histochemica, 2019, 121(6):718-723. doi: S0065-1281(19)30167-9 pmid: 31253359
[67]	YANG S, PING P, MA M, et al. Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of cryptorchid patients[J]. Stem cell reports, 2014, 3(4):663-675. doi: 10.1016/j.stemcr.2014.08.004 pmid: 25358793
[68]	BISIG C G, GUIRALDELLI M F, KOUZNETSOVA A, et al. Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes[J]. Plos genetics, 2012, 8(6):e1002701.
[69]	谢慧, 龚小雯, 李小勇. 维甲酸诱导精原干细胞分化过程中DNA甲基转移酶表达研究[J]. 基因组学与应用生物学, 2018, 37(6):2572-2578.
[70]	DAGUIA ZAMBE J C, ZHAI Y, ZHOU Z, et al. miR-19b-3p induces cell proliferation and reduces heterochromatin‐mediated senescence through PLZF in goat male germline stem cells[J]. Journal of cellular physiology, 2018, 233(6):4652-4665. doi: 10.1002/jcp.v233.6 URL
[71]	马仕昆, 郭佳倩, 郑哲, 等. Stra8在精子发生中的研究进展[J]. 医学综述, 2015, 21(14):2500-2502.
[72]	彭金普. 视黄酸促隐睾大鼠生精功能修复的作用及机制研究[D]. 重庆: 重庆医科大学, 2016.
[73]	SINHA N, WHELAN E C, TOBIAS J W, et al. Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse[J]. Biology of reproduction, 2021, 105(2):503-518. doi: 10.1093/biolre/ioab093 pmid: 33959758
[74]	SONG W, SHI X, XIA Q, et al. PLZF suppresses differentiation of mouse spermatogonial progenitor cells via binding of differentiation associated genes[J]. Journal of cellular physiology, 2020, 235(3):3033-3042. doi: 10.1002/jcp.29208 pmid: 31541472
[75]	SHARMA M, SRIVASTAVA A, FAIRFIELD H E, et al. Identification of EOMES-expressing spermatogonial stem cells and their regulation by PLZF[J]. Elife, 2019, 8:e43352. doi: 10.7554/eLife.43352 URL
[76]	UNNI S K, MODI D N, PATHAK S G, et al. Stage-specific localization and expression of c-kit in the adult human testis[J]. Journal of histochemistry & cytochemistry, 2009, 57(9):861-869. doi: 10.1369/jhc.2009.953737 URL
[77]	SIKARWAR A P, REDDY K V R. siRNA-mediated silencing of c-kit in mouse primary spermatogonial cells induces cell cycle arrest[J]. Oligonucleotides, 2008, 18(2):145-160. doi: 10.1089/oli.2008.0108 pmid: 18637732
[78]	ZHU W Q, CAI N N, JIANG Y, et al. Survivable potential of germ cells after trehalose cryopreservation of bovine testicular tissues[J]. Cryobiology, 2021, 101:105-114. doi: 10.1016/j.cryobiol.2021.05.001 URL
[79]	WEN Q, TANG E I, XIAO X, et al. Transport of germ cells across the seminiferous epithelium during spermatogenesis—the involvement of both actin-and microtubule-based cytoskeletons[J]. Tissue Barriers, 2016, 4(4):e1265042.
[80]	COUTURE R, MARTIN L J. The transcription factors SF-1 and SOX8 cooperate to upregulate Cx43 expression in mouse TM4 sertoli cells[J]. Biochemistry and biophysics reports, 2020, 24:100828. doi: 10.1016/j.bbrep.2020.100828 URL
[81]	CHUNG S S W, CHOI C, WANG X, et al. Aberrant distribution of junctional complex components in retinoic acid receptor alpha‐deficient mice[J]. Microscopy research and technique, 2010, 73(6):583-596.
[82]	CHUNG S S W, WANG X, WOLGEMUTH D J. Male sterility in mice lacking retinoic acid receptor α involves specific abnormalities in spermiogenesis[J]. Differentiation, 2005, 73(4):188-198. doi: 10.1111/j.1432-0436.2005.00018.x URL
[83]	CHIHARA M, OTSUKA S, ICHII O, et al. Vitamin A deprivation affects the progression of the spermatogenic wave and initial formation of the blood-testis barrier, resulting in irreversible testicular degeneration in mice[J]. Journal of reproduction and development, 2013.
[84]	ISMAIL N, MORALES C R. Effects of vitamin A deficiency on the inter-Sertoli cell tight junctions and on the germ cell population[J]. Microscopy research and technique, 1992, 20(1):43-49. pmid: 1611150