Abstract: The paper aims to investigate the dynamic changes of physical and chemical parameters during aerobic composting process of 3 typical kinds of manure amended with mushroom dregs, so as to provide a theoretical basis for resourceful treatment of these wastes to be organic fertilizer. The authors adopted industrialized thermophilic aerobic composting process to investigate the composting efficiency for the mixtures of fresh cow dung, pig manure and chicken manure-based materials amended with mushroom dregs at the primary ratio of 1:2, and to monitor the dynamic changes of the temperature, pH value, ammonium nitrate and other physical and chemical indicators during composting. The results showed that: during composting, all piles with temperature above 55℃ lasted for more than 15 days; and temperature in all piles reached 70℃; at the end of composting, the pH value of samples from cow dung, pig manure and chicken manure- based treatments was 7.59, 7.81, and 7.48, respectively, in line with the general standard that the compost pH value should be between 5.5 to 8.5; the germination index of the produced composts were all higher than 80%; and the total nutrient (N + P2O5 + K2O) was 4.31% , 5.01% , and 4.57% , respectively, only the chicken manure treatment satisfied the organic manure nutrient standard (NY 525-2012); ammonium nitrogen content of all treatments gradually decreased by 45.6% , 29.2% and 33.9% , respectively, while nitrate nitrogen amount increased to 2.59 g/kg, 2.57 g/kg, 2.15 g/kg, respectively. The results can provide a theoretical basis for a moderate scale farm to produce organic fertilizer.