Red Beet and Betacyanins: Research Progress on Comprehensive Application

doi:10.11924/j.issn.1000-6850.casb2022-0033

Abstract

Abstract:

In this paper, the active components and biological functions of red beet root were summarized, and the application progress of red beet and betacyanins in bacteriostasis, antimalarial, anti-inflammatory, anti-virus, cardiovascular protection, cell protection and neuroprotection were analyzed. As an additive and main nutritional component, the biological value of red beet in beverages, meat products and functional foods were reviewed. In addition, this paper also briefly described the biological characteristics of red beet in the process of planting, such as salt and alkali tolerance and water purification, as well as the application of betacyanins in the field of environmental protection in recent years. It can be seen that red beet and its related industries have great development potential and value.

Key words: red beet, betacyanins, application, review

CLC Number:

S566.3

LIU Yaxin, YAN Hua, TANG Ling, TAN Wenbo, XING Wang, LIU Dali. Red Beet and Betacyanins: Research Progress on Comprehensive Application[J]. Chinese Agricultural Science Bulletin, 2022, 38(13): 157-164.

References 69

[1]	KANNER J, HAREL S, GRANIT R. Betalains- A new class of dietary cationized antioxidants[J]. Journal of agricultural and food chemistry, 2001, 49(11):5178-5185. doi: 10.1021/jf010456f URL
[2]	RAVICHANDRAN K, SAW N M M T, MOHDALY A A A, et al. Impact of processing of red beet on betalain content and antioxidant activity[J]. Food research international, 2013, 50(2):670-675. doi: 10.1016/j.foodres.2011.07.002 URL
[3]	郝秀梅. 甜菜红色素的分离纯化及抗氧化与抗疲劳活性的研究[D]. 哈尔滨: 东北林业大学, 2011.
[4]	GENGATHARAN A, DYKES G A, CHOO W S. Betalains: Natural plant pigments with potential application in functional foods[J]. LWT-Food science and technology, 2015, 64(2):645-649. doi: 10.1016/j.lwt.2015.06.052 URL
[5]	JASNA M, CANADANOVIC-BRUNET S S, SAVATOVIC G S, et al. Antioxidant and antimicrobial activities of beet root pomace extracts[J]. Czech journal of food science, 2011, 29:575-585. doi: 10.17221/210/2010-CJFS URL
[6]	VULIĆ J J, CEBOVIĆ T N, CANADANOVIĆ V M, et al. Antiradical, antimicrobial and cytotoxic activities of commercial beetroot pomace[J]. Food & function, 2013, 4(5):713-721.
[7]	TENORE G C, NOVELLINO E, BASILE A. Nutraceutical potential and antioxidant benefits of red pitaya (Hylocereus polyrhizus) extracts[J]. Journal of functional foods, 2012, 4(1):129-136. doi: 10.1016/j.jff.2011.09.003 URL
[8]	RECORD N B, ONION D K, PRIOR R E, et al. Community-wide cardiovascular disease prevention programs and health outcomes in a rural county, 1970-2010[J]. Jama, 2015, 313(2):147-155. doi: 10.1001/jama.2014.16969 URL
[9]	FARINAZZI-MACHADO F M V, BARBALHO S M, OSHIIWA M, et al. Use of cereal bars with quinoa (Chenopodium quinoa W.) to reduce risk factors related to cardiovascular diseases[J]. Food science and technology, 2012, 32:239-244. doi: 10.1590/S0101-20612012005000040 URL
[10]	DE CARVALHO F G, OVÍDIO P P, PADOVAN G J, et al. Metabolic parameters of postmenopausal women after quinoa or corn flakes intake- a prospective and double-blind study[J]. International journal of food sciences and nutrition, 2014, 65(3):380-385. doi: 10.3109/09637486.2013.866637 URL
[11]	RAHIMI P, MESBAH-NAMIN S A, OSTADRAHIMI A, et al. Effects of betalains on atherogenic risk factors in patients with atherosclerotic cardiovascular disease[J]. Food & function, 2019, 10(12):8286-8297.
[12]	LITWIN N S, VAN ARK H J, HARTLEY S C, et al. Impact of red beetroot juice on vascular endothelial function and cardiometabolic responses to a high-fat meal in middle-aged/older adults with overweight and obesity: a randomized, double-blind, placebo-controlled, crossover trial[J]. Current developments in nutrition, 2019, 3(11):113.
[13]	MADADI E, MAZLOUM-RAVASAN S, YU J S, et al. Therapeutic application of betalains: A review[J]. Plants, 2020, 9(9):1219. doi: 10.3390/plants9091219 URL
[14]	ZIELIŃSKA-PRZYJEMSKA M, OLEJNIK A, KOSTRZEWA A, et al. The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils[J]. Phytotherapy research, 2012, 26(6):845-852. doi: 10.1002/ptr.3649 URL
[15]	ALBASHER G, ALBRAHIM T, ALSULTAN N, et al. Red beetroot extract mitigates chlorpyrifos-induced reprotoxicity associated with oxidative stress, inflammation, and apoptosis in rats[J]. Environmental science and pollution research, 2020, 27(4):3979-3991. doi: 10.1007/s11356-019-07009-6 URL
[16]	KLEWICKA E, NOWAK A, ZDUŃCZYK Z, et al. Protective effect of lactofermented red beetroot juice against aberrant crypt foci formation, genotoxicity of fecal water and oxidative stress induced by 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine in rats model[J]. Environmental toxicology and pharmacology, 2012, 34(3):895-904. doi: 10.1016/j.etap.2012.08.009 URL
[17]	DAI R, WANG Y, WANG N. Betalain alleviates airway inflammation in an ovalbumin-induced-asthma mouse model via the TGF- beta;1/Smad signaling pathway[J]. Journal of environmental pathology, toxicology and oncology, 2021, 40(2):11-21.
[18]	STARZAK K, SUTOR K, ŚWIERGOSZ T, et al. The responses of bioactive betanin pigment and its derivatives from a red beetroot (Beta vulgaris L.) betalain-rich extract to hypochlorous acid[J]. International journal of molecular sciences, 2021, 22(3):1155. doi: 10.3390/ijms22031155 URL
[19]	PIETRZKOWSKI Z, NEMZER B, SPÓRNA A, et al. Influence of betalain-rich extract on reduction of discomfort associated with osteoarthritis[J]. New med, 2010, 1:12-17.
[20]	PIETRZKOWSKI Z, ARGUMEDO R, SHU C, et al. Betalain-rich red beet concentrate improves reduced knee discomfort and joint function: a double blind, placebo-controlled pilot clinical study[J]. Nutrition and dietary supplements, 2014, 9:895-899.
[21]	CALABRÒ M, RINALDI C, SANTORO G, et al. The biological pathways of alzheimer disease: A review[J]. AIMS neuroscience, 2021, 8(1):86-132. doi: 10.3934/Neuroscience.2021005 URL
[22]	GHONEIM F M, KHALAF H A, ELSAMANOUDY A Z, et al. Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer’s disease[J]. International journal of clinical and experimental pathology, 2015, 8(7):7710.
[23]	PRINCE M, BRYCE R, ALBANESE E, et al. The global prevalence of dementia: A systematic review and metaanalysis[J]. Alzheimer's & dementia: The journal of the Alzheimer's association, 2013, 9(1):63-75.
[24]	SHUNAN D, YU M, GUAN H, et al. Neuroprotective effect of Betalain against AlCl₃-induced Alzheimer's disease in Sprague Dawley Rats via putative modulation of oxidative stress and nuclear factor kappa B (NF-κB) signaling pathway[J]. Biomedicine & pharmacotherapy, 2021, 137:111369. doi: 10.1016/j.biopha.2021.111369 URL
[25]	THENMOZHI A J, RAJA T R W, JANAKIRAMAN U, et al. Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer’s disease in Wistar rats[J]. Neurochemical research, 2015, 40(4):767-776. doi: 10.1007/s11064-015-1525-1 URL
[26]	SADOWSKA-BARTOSZ I, BARTOSZ G. Biological properties and applications of betalains[J]. Molecules, 2021, 26(9):2520. doi: 10.3390/molecules26092520 URL
[27]	HADIPOUR E, FEREIDONI M, TAYARANI-NAJARAN Z. Betanin attenuates oxidative stress induced by 6-OHDA in PC12 cells via SAPK/JNK and PI3 K pathways[J]. Neurochemical research, 2020, 45(2):395-403. doi: 10.1007/s11064-019-02927-w URL
[28]	CHANG Y J, PONG L Y, HASSAN S S, et al. Antiviral activity of betacyanins from red pitahaya (Hylocereus polyrhizus) and red spinach (Amaranthus dubius) against dengue virus type 2 (GenBank accession no. MH488959)[J]. Access microbiology, 2019, 2(1):73.
[29]	TALLEI T E, TUMILAAR S G, LOMBOGIA L T, et al. Potential of betacyanin as inhibitor of SARS-CoV-2 revealed by molecular docking study[A].//IOP conference series: Earth and environmental science[C]. IOP Publishing, 2021, 711(1):012028.
[30]	SHEDID S M, ABDEL-MAGIED N, SAADA H N. Role of betaine in liver injury induced by the exposure to ionizing radiation[J]. Environmental toxicology, 2019, 34(2):123-130. doi: 10.1002/tox.22664 URL
[31]	VASCONCELLOS J, CONTE-JUNIOR C, SILVA D, et al. Comparison of total antioxidant potential, and total phenolic, nitrate, sugar, and organic acid contents in beetroot juice, chips, powder, and cooked beetroot[J]. Food science and biotechnology, 2016, 25(1):79-84. doi: 10.1007/s10068-016-0011-0 URL
[32]	吕思润. 甜菜红素的提取纯化及其生物活性研究[D]. 哈尔滨: 哈尔滨工业大学, 2016.
[33]	章传华. 红甜菜粕膳食纤维直接生产的保健食品[P]. 中国专利, 2005100571992, 2011-12-21.
[34]	章传华. 一种红甜菜格瓦斯[P]. 中国专利, 2004100404143, 2010-05-12.
[35]	章传华. 红甜菜可乐及其制备方法[P]. 中国专利, 200510020378, 2010-04-28.
[36]	章传华. 红甜菜啤酒及其酿造方法[P]. 中国专利, 2004100813925, 2010-04-14.
[37]	章传华. 红甜菜朗姆酒[P]. 中国专利, 2006100541370, 2012-01-11.
[38]	YANG W, KAIMAINEN M, JÄRVENPÄÄ E, et al. Red beet (Beta vulgaris) betalains and grape (Vitis vinifera) anthocyanins as colorants in white currant juice- Effect of storage on degradation kinetics, color stability and sensory properties[J]. Food chemistry, 2021, 348:128995. doi: 10.1016/j.foodchem.2020.128995 URL
[39]	Park Y O. Quality characteristics and antioxidant activities of combined fruit and vegetable juice according to the mixing ratio of red beet and apple juice[J]. Journal of the Korean society of food science and nutrition, 2019, 48(11):1253-1261. doi: 10.3746/jkfn.2019.48.11.1253 URL
[40]	DABIJA A, CODINA G G, ROPCIUC S, et al. Studies regarding the production of a novel yogurt using some local plant raw materials[J]. Journal of food processing & preservation, 2019, 43(6):1-9.
[41]	GHASEMPOUR Z, JAVANMARD N, LANGROODI A M, et al. Development of probiotic yogurt containing red beet extract and basil seed gum; techno-functional, microbial and sensorial characterization[J]. Biocatalysis and agricultural biotechnology, 2020, 29:101785. doi: 10.1016/j.bcab.2020.101785 URL
[42]	GENGATHARAN A, DYKES G A, CHOO W S. Stability of betacyanin from red pitahaya (Hylocereus polyrhizus) and its potential application as a natural colourant in milk[J]. International journal of food science & technology, 2016, 51(2):427-434.
[43]	GENGATHARAN A, DYKES G A, CHOO W S. The effect of pH treatment and refrigerated storage on natural colourant preparations (betacyanins) from red pitahaya and their potential application in yoghurt[J]. LWT, 2017, 80:437-445. doi: 10.1016/j.lwt.2017.03.014 URL
[44]	GENGATHARAN A, DYKES G, CHOO W S. Betacyanins from Hylocereus polyrhizus: Pectinase-assisted extraction and application as a natural food colourant in ice cream[J]. Journal of food science and technology, 2021, 58(4):1401-1410. doi: 10.1007/s13197-020-04651-8 URL
[45]	LEE K Y, KIM A N, RAHMAN M S, et al. Effect of red beet (Beta vulgaris L.) powder addition on physicochemical and microbial characteristics of tofu[J]. Korean journal of food preservation, 2019, 26(6):659-666. doi: 10.11002/kjfp.2019.26.6.659 URL
[46]	JEONG H J, LEE H C, CHIN K B. Effect of red beet on quality and color stability of low-fat sausages during refrigerated storage[J]. Food science of animal resources, 2010, 30(6):1014-1023.
[47]	MCMAHON N F, LEVERITT M D, PAVEY T G. The effect of dietary nitrate supplementation on endurance exercise performance in healthy adults: A systematic review and meta-analysis[J]. Sports medicine, 2017, 47(4):735-756. doi: 10.1007/s40279-016-0617-7 URL
[48]	JIN S K, HA S R, CHOI J S. Effect of Caesalpinia sappan L. extract on physico-chemical properties of emulsion-type pork sausage during cold storage[J]. Meat science, 2015, 110:245-252. doi: 10.1016/j.meatsci.2015.08.003 URL
[49]	Functional beverages ‘feel the beet’[J]. Beverage industry, 2014, 105(6):72-73.
[50]	TIAN Y S, FU X Y, YANG Z Q, et al. Metabolic engineering of rice endosperm for betanin biosynthesis[J]. New phytologist, 2020, 225(5):1915-1922. doi: 10.1111/nph.16323 URL
[51]	章传华, 钟惠青, 杨欣, 等. 红甜菜浸膏或浸膏粉以及用其制备的系列产品[P]. 中国专利, CN101095492, 2008-01-01.
[52]	刘琪龙, 韩海霞, 包晓玮, 等. 甜菜红素喷雾干燥粉抗氧化活性及其咀嚼片的研制[J]. 新疆农业科学, 2021, 58(6):1145-1153. doi: 10.6048/j.issn.1001-4330.2021.06.020
[53]	MORGADO M, DE OLIVEIRA G V, VASCONCELLOS J, et al. Development of a beetroot-based nutritional gel containing high content of bioaccessible dietary nitrate and antioxidants[J]. International journal of food sciences and nutrition, 2016, 67(2):153-160. doi: 10.3109/09637486.2016.1147531 URL
[54]	VITALI V, SUTKA M, OJEDA L, et al. Root hydraulics adjustment is governed by a dominant cell-to-cell pathway in Beta vulgaris seedlings exposed to salt stress[J]. Plant science, 2021, 306:110873. doi: 10.1016/j.plantsci.2021.110873 URL
[55]	陈永华, 吴晓芙, 陈明利, 等. 人工湿地污水处理系统冬季植物的筛选与评价[J]. 环境科学, 2010, 31(8):1789-1794.
[56]	李卫星, 李长菊, 熊作明, 等. 水培蔬菜对城市河道污水净化的研究[J]. 扬州大学学报:农业与生命科学版, 2016, 37(3):120-126.
[57]	SHARMA K, SHARMA V, SHARMA S S. Dye-sensitized solar cells: fundamentals and current status[J]. Nanoscale research letters, 2018, 13(1):1-46. doi: 10.1186/s11671-017-2411-3 URL
[58]	JOSHI P H, KORFIATIS D P, POTAMIANOU S F, et al. Selected parameters leading to an optimized DSSC performance[J]. Russian journal of electrochemistry, 2013, 49(7):628-632. doi: 10.1134/S1023193513070045 URL
[59]	RAMAMOORTHY R, RADHA N, MAHESWARI G, et al. Betalain and anthocyanin dye-sensitized solar cells[J]. Journal of applied electrochemistry, 2016, 46(9):929-941. doi: 10.1007/s10800-016-0974-9 URL
[60]	ZHANG D, LANIER S M, DOWNING J A, et al. Betalain pigments for dye-sensitized solar cells[J]. Journal of photochemistry and photobiology A: Chemistry, 2008, 195(1):72-80. doi: 10.1016/j.jphotochem.2007.07.038 URL
[61]	PATNI N G, PILLAI S, SHARMA P. Effect of using betalain, anthocyanin and chlorophyll dyes together as a sensitizer on enhancing the efficiency of dye-sensitized solar cell[J]. International journal of energy research, 2020, 44(13):10846-10859. doi: 10.1002/er.5752 URL
[62]	SENGUPTA D, MONDAL B, MUKHERJEE K. Visible light absorption and photo-sensitizing properties of spinach leaves and beetroot extracted natural dyes[J]. Spectrochimica acta part A: Molecular and biomolecular spectroscopy, 2015, 148:85-92. doi: 10.1016/j.saa.2015.03.120 URL
[63]	CHAUBEY N, QURASHI A, CHAUHAN D S, et al. Frontiers and advances in green and sustainable inhibitors for corrosion applications: A critical review[J]. Journal of molecular liquids, 2021, 321:114385. doi: 10.1016/j.molliq.2020.114385 URL
[64]	ASHASSI-SORKHABI H, ES’HAGHI M. Corrosion inhibition of mild steel in hydrochloric acid by betanin as a green inhibitor[J]. Journal of solid state electrochemistry, 2009, 13(8):1297-1301. doi: 10.1007/s10008-008-0673-5 URL
[65]	PIRSA S, MOHTARAMI F, KALANTARI S. Preparation of biodegradable composite starch/tragacanth gum/nanoclay film and study of its physicochemical and mechanical properties[J]. Chemical review and letters, 2020, 3(3):98-103.
[66]	OTONI C G, AVENA-BUSTILLOS R J, AZEREDO H M C, et al. Recent advances on edible films based on fruits and vegetables- A review[J]. Comprehensive reviews in food science and food safety, 2017, 16(5):1151-1169. doi: 10.1111/1541-4337.12281 URL
[67]	OTÁLORA GONZÁLEZ C M, DE’NOBILI M D, ROJAS A M, et al. Development of functional pectin edible films with fillers obtained from red cabbage and beetroot[J]. International journal of food science & technology, 2021, 56(8):3662-3669.
[68]	ZHENG L, LIU L, YU J, et al. Novel trends and applications of natural pH-responsive indicator film in food packaging for improved quality monitoring[J]. Food control, 2021:108769.
[69]	NAGHDI S, REZAEI M, ABDOLLAHI M. A starch-based pH-sensing and ammonia detector film containing betacyanin of paperflower for application in intelligent packaging of fish[J]. International journal of biological macromolecules, 2021, 191:161-170. doi: 10.1016/j.ijbiomac.2021.09.045 URL